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What Is NAD+?

NAD+ stands for Nicotinamide Adenine Dinucleotide, a coenzyme found in all living cells. It plays an essential role in cellular energy production and metabolic processes. NAD+ exists in two forms:

NAD+ (Oxidized form): Ready to accept electrons.

NADH (Reduced form): After accepting electrons, it carries energy used for cellular functions.

NAD+ is often referred to as the “molecular currency” of energy, as it facilitates critical biochemical reactions necessary for sustaining life.

Functions of NAD+ in the Body

Energy Production

NAD+ is central to cellular respiration, the process by which cells convert food (glucose) into usable energy (ATP).

It acts as an electron carrier during glycolysis, the citric acid cycle, and oxidative phosphorylation.

DNA Repair

It activates enzymes like PARPs (Poly ADP-Ribose Polymerases) that detect and repair DNA damage, maintaining genetic integrity.

Regulation of Cellular Aging

NAD+ activates sirtuins, proteins that influence cellular health, inflammation, metabolism, and aging.

High NAD+ levels are associated with longevity and reduced cellular decline.

Stress Response and Immune Function

NAD+ modulates immune responses and helps reduce inflammation by regulating immune cell activity.

Antioxidant Support

NAD+ is involved in regenerating antioxidants like glutathione, protecting cells from oxidative damage caused by free radicals.


Decline of NAD+ with Age

NAD+ levels naturally decline as we age, contributing to:

• Reduced energy production.

• Increased cellular damage and oxidative stress.

• Slower DNA repair and cellular recovery.

• Higher susceptibility to age-related diseases like Alzheimer’s, diabetes, and cardiovascular issues.

This decline has sparked interest in replenishing NAD+ levels through supplementation, lifestyle changes, and therapeutic interventions.

How to Increase NAD+ Levels

  • NAD+ Precursors

  • Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are supplements that boost NAD+ levels.

    Diet and Lifestyle

    Foods like milk, fish, and mushrooms contain small amounts of NAD+ precursors.

    Practices like fasting and regular exercise can naturally enhance NAD+ production.

    NAD+ Injections and IV Therapy

    Direct administration of NAD+ through IV infusions ensures immediate bioavailability.

    Sirtuin-Activating Foods

    Resveratrol (found in red wine) and other polyphenols may indirectly support NAD+ levels by activating sirtuins.

Potential Benefits of NAD+ Therapy

Improved Energy Levels: Supports mitochondrial function for sustained energy.

Anti-Aging Effects: Enhances DNA repair and reduces cellular damage.

Better Brain Function: Protects neurons, improves cognitive performance, and may reduce the risk of neurodegenerative diseases.

Metabolic Health: Helps regulate blood sugar levels and improve insulin sensitivity.

Enhanced Recovery: Aids in muscle repair and reduces inflammation, particularly beneficial for athletes.

Functions of NAD+

Energy Production

NAD+ is essential in converting food into energy. It acts as a carrier for electrons during the metabolic processes of glycolysis, the citric acid cycle, and oxidative phosphorylation in mitochondria.

By cycling between NAD+ and NADH, it helps drive ATP production, the primary energy currency of the cell.

Cellular Repair

NAD+ supports DNA repair by activating enzymes such as PARPs (Poly ADP-Ribose Polymerases). These enzymes fix DNA damage to maintain cellular health and prevent mutations.

Regulation of Cellular Processes

It is a coenzyme for sirtuins, proteins involved in regulating metabolism, stress responses, and aging. Sirtuins rely on NAD+ to function, which links NAD+ levels to longevity and cellular health.

Immune Function and Inflammation

NAD+ influences immune responses and reduces chronic inflammation by modulating immune cells and inflammatory pathways.

Antioxidant Defense

It helps regenerate antioxidants like glutathione, which protect cells from oxidative stress and damage caused by free radicals.

Applications of NAD+ in Health and Medicine

Aging

NAD+ levels decline with age, which is linked to reduced energy, impaired metabolism, and age-related diseases. Boosting NAD+ may help improve mitochondrial function and combat aging.

Neuroprotection

NAD+ supports brain health by protecting neurons and promoting repair processes. It is being studied for its role in neurodegenerative diseases like Alzheimer’s and Parkinson’s.

Metabolic Disorders

Increasing NAD+ levels can improve insulin sensitivity, making it a potential target for managing type 2 diabetes and obesity.

Supplementation and Therapy

NAD+ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are widely used as supplements to increase NAD+ levels.

NAD+ infusions are also being explored for fatigue, addiction recovery, and enhancing athletic performance.

Most Asked Q&A

Most Asked Q&A

Most Asked Q&A Most Asked Q&A

What is NAD+ therapy?

NAD+ therapy involves administering NAD+ (Nicotinamide Adenine Dinucleotide), a naturally occurring coenzyme, through intravenous (IV) infusions or other forms to replenish declining levels in the body. This helps improve energy production, repair DNA, and support overall cellular health.

What are the benefits of NAD+ therapy?

NAD+ therapy offers numerous benefits, including:

  • Increased energy and reduced fatigue.

  • Enhanced cognitive function and mental clarity.

  • Slowed aging and improved skin health.

  • Faster recovery from physical exertion or illness.

  • Support for addiction recovery by repairing brain cells.

  • Improved metabolic health and weight management.

How does NAD+ work?

NAD+ acts as a coenzyme in cellular processes that produce energy, repair DNA, and regulate stress responses. By restoring NAD+ levels, therapy boosts mitochondrial function and promotes overall cell vitality.

Who can benefit from NAD+ therapy?

NAD+ therapy is suitable for a wide range of individuals, including:

  • Those experiencing chronic fatigue or low energy.

  • Individuals seeking anti-aging solutions.

  • People recovering from illness, addiction, or physical strain.

  • Athletes looking to enhance recovery and performance.

  • Anyone interested in improving overall wellness and longevity.

Is NAD+ therapy safe?

Yes, NAD+ therapy is considered safe when administered by trained professionals. Since NAD+ is a natural compound already found in your body, the risk of adverse reactions is minimal. Some people may experience mild side effects like nausea or flushing during the infusion.

How long does an NAD+ therapy session take?

A typical NAD+ infusion session lasts between 2 to 4 hours, depending on the dosage and individual needs.

How often should I get NAD+ therapy?

Frequency depends on your health goals and current condition. Some people benefit from weekly sessions, while others may need only monthly treatments for maintenance.

Are there any side effects?

Mild side effects can include:

  • Nausea

  • Flushing or warmth during the infusion

  • Fatigue (temporary)

These effects usually subside quickly and can be minimized with proper hydration and monitoring.

What’s the difference between NAD+ therapy and oral supplements?

Oral NAD+ supplements like NMN and NR can help increase NAD+ levels over time, but IM therapy provides a direct, immediate boost with higher bioavailability, making it more effective for rapid results.

Can NAD+ therapy help with addiction recovery?

Yes, NAD+ therapy is often used in addiction recovery programs. It helps replenish depleted NAD+ levels, repair brain cells, and reduce cravings, which supports the recovery process.

Is NAD+ therapy suitable for everyone?

While NAD+ therapy is generally safe, it may not be recommended for individuals with specific medical conditions or those who are pregnant or breastfeeding. Always consult with a healthcare provider before starting treatment.

How soon will I notice results?

Some individuals feel more energized and focused after their first session, while others may need multiple sessions to experience noticeable improvements. Results vary based on health status and goals.

Have more questions? Contact our team for personalized guidance and to see if NAD+ therapy is right for you.