NEWEST GENERATION OF SKIN BOOSTER, on the market. PN mesotherapy treatments make a significant improvement in skin elasticity, texture and hydration. PN also has been proven to be effective and safe through dermatology clinics for cell and tissue growth
What Are Polynucleotides (Pn)?
what are polynucleotides, exactly, and how can they help resolve your patients’ top concerns?
In the world of aesthetics, polynucleotides are known as the future of regenerative injectables – hailed for their ability to rejuvenate and regenerate the skin, similarly to skin boosters. However, unlike skin boosters, injectable polynucleotides are renowned for their wound-healing and bio-stimulating properties. Although similar to skin boosters, polynucleotide injectables are separated and well-recognised for their complex structures and ability to rejuvenate the skin with a natural result.
Taking a scientific approach to ‘what are polynucleotides’, these injectables employ filtered, ultra-purified, and sterilised DNA fractions with the aim of rejuvenating the skin. Predominantly derived from salmon DNA*, polynucleotides are designed to stimulate fibroblasts, promoting tissue repair, enhancing cell turnover, increasing elasticity, and stimulating collagen production. Additionally, they possess the ability to soothe inflammation and restore the balance of melanocyte activity (skin pigmentation), resulting in a more even and refreshed skin tone without adding volume like traditional dermal fillers.
Also frequently known as PN or PDRN, polynucleotides are categorised as a regenerative treatment with the purpose of revitalising the skin on a deeper level. Each polynucleotide strand consists of a repeating pattern of a sugar molecule and a phosphate group. DNA and RNA represent the two main categories of nucleic acids. In simpler terms, these injectables essentially provide DNA molecules that encourage the skin to repair itself and promote various skin-boosting benefits, both immediate and long-term. This exciting advancement in regenerative medicine focuses on restoring normal cellular function by repairing the skin on a more intense level.
Like many other regenerative medicine tools, polynucleotides have a long history of being used in general medicine before their introduction to the world of medical aesthetics with over 90 clinical trials to back this up. Studies have reported their successful treatments with the evidence for polynucleotide’s power remaining undisputed in both the medical and aesthetic fields.
Understanding polynucleotides
PDRN stands for Polydeoxyribonucleotide, a bond molecule created using salmon DNA fragments. These molecules carry the remarkable ability to stimulate cell growth in tissues and speed up wound healing, therefore improving the physiological condition and elasticity of the skin, leaving it healthy and natural.
Polydeoxyribonucleotide (PDRN) contains deoxyribonucleotide polymers (DNA is a linear double stranded polymer made up of deoxyribonucleotides).
Deoxyribonucleotide is made up of a sugar called deoxyribose, a nitrogenous base and a phosphate group. DNA is located in the nucleus) . 50 to 2000 base pairs are combined in a chain.
It’s main claim to fame amongst aesthetic circles is its remarkable ability to aid regeneration of skin and tissue. PDRN was shown to enhance the growth rate of human fibroblasts in primary cultures at therapeutic concentrations.
PDRN exists in small amounts in newly formed tissues. It standardised the DNA structure into the right size, replacing the damaged and aged skin with young and healthy skin.
As a deoxyribonucleotide linear polymer PDRN selectively acts on the A2 purinergic receptor to help cell growth and neogenesis (Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules that are found in almost all mammalian tissues. More specifically, they are involved in several cellular functions, including proliferation and migration of neural stem cells, vascular reactivity, apoptosis and cytokine secretion).
PDRN is derived from a controlled purification and sterilisation process of Oncorhynchus mykiss (Salmon Trout) or Oncorhynchus keta (Chum Salmon) sperm DNA.
Salmon DNA fragments called polynucleotides (PN) and poly deoxyribonucleotides (PDRN) are the star ingredients of this very popular anti-aging and rejuvenating skin treatment.
These salmon DNA fragments, PDRN and PN, have been found to improve blood circulation; enhance collagen formation and reduce inflammation in the skin when injected into the skin. This leads to skin healing and improvements in skin texture, hydration and wrinkles. Now because of all these benefits, PN is used to rejuvenate skin and treat depressed acne scars, dry skin and pores.
It has been used for clinical treatment of orthopedic conditions such as forms of chronic tendinosis and certain skin ulcers, with improved wound healing, relief of skin edema and reduction of pain. In 2008, it was approved for use in tissue repair and treatment of wound in skin graft by Korean FDA.
PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers.
The procedure guarantees the absence of active protein and peptides that may cause immune reactions. The binding to adenosine A2A receptors is a unique property of PDRN/PN and seems to be linked to DNA origin, molecular weight and manufacturing process. In this context, PDRN and PN represents a new advancement in the pharmacotherapy.
WHAT IS A NUCLEOTIDE
So first lets look at DNA/RNA - In DNA (double helix) there are two antiparallel strands of polynucleotides that are linked together by hydrogen bonds between nitrogenous bases. Purine pairs with pyrimidine base, A pairs with T and G pairs with C by two and three hydrogen bonds respectively.
In RNA instead of thymine (T), A pairs with U.
Phosphate group interlinks the sugar molecules of two nucleotides forming a chain. DNA and RNA are polynucleotides. Sugar phosphate chain forms the backbone of a polynucleotide chain.
So to explain this in a more simplified way. In our cells we have a nuclues, within the nucleus we have chromosomes which are made up of compact DNA strands, each strand forms a Double Helix.
Next if we uncoil that Double Helix into a ladder view (DNA STRAND UNCOILED), We can start to break it down to find what a nucleotide is. So the two strands that make up the ladder (in blue) are made up of Deoxyribose sugar and phostphate. They connect to a Nitrogen base, the base then pairs up with another nitrogen base that again attaches to the sugar and phosphate.
If we circle just one side (step to the ladder), this is what we call a Nucleotide. This molecule is also known as monomer nucleotide.
So to make a polynucleotide we would have chains of nucleotides together. Now putting together 2 chains of polynucleotides, they then make up a double helix structure of DNA.
I DISCUSS THIS ON THE VIDEO IN DEPTH, HOWEVER THIS IS THE BASICS TO HELP YOU UNDERSTAND.
FACTS
PDRN and PN is material extracted from salmon sperm and testicle. It is used to treat wound and to regenerate skin tissue.
Used for pressure sore, wound, skin graft, skin plasty, etc.
Also called as Baby Skin, Skin Boosters, DNA injection or salmon injection
PDRN / PN action mechanism
PDRN / PN acts selectively on the purine receptor, promoting VEGG (Vascular Endothical Growth Factor) and inducing vascularisation.
PDRN / PN increases fibroblasts and activates secretion.
PDRN / PN maintains the pharmacological action without being destroyed by high temperature treatment.
Advantages of PDRN / PN
Safe material that does not present reaction of foreign substance
Increases elasticity of epidermal and dermal layers
Stable against heat
Biocompatible material made by cutting DNA to a certain size
Restores skin damaged by UV or skin irritation
PN AND PDRN
Polynucleotides (PNs) refer to as a broader group of molecules. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are all PNs. On the other hand, PRDN – Polydeoxyribonucleotides, refer to a subtype of PNs. PN BOOSTER contains PNs – which also includes PDRN. These molecules contain large amounts of omega-3 fatty acids and are packed with anti-oxidant properties (Anti-oxidants neutralize free radicals which are harmful to our skin cells). Polynucleotide chains are DNA fragments that repair damaged dermal (skin) cells and assist in collagen stimulation.
Most often you may hear other people calling it PDRN or PN too. For your information, PN stands for polynucleotide which is basically an element our DNA is made of. While PDRN is also a type of PN which stands for Polydeoxyribonucleotides.
PN is a purer and more concentrated form of PDRN and has stronger regenerative properties.
The use of PN in skin rejuvenation is mainly based on its potent wound healing and anti-inflammatory properties. Many studies have shown that PN stimulates wound healing and cell growth. These molecules have been proven to stimulate long-term skin regeneration from within the inner skin layer, therefore improving skin elasticity, skin health and restores skin damage caused by harmful UV rays and ageing.
PN contributes to the regeneration of several autologous key components of the skin such as glycosaminoglycan, proteins, glycoproteins, and fibrils, helping to maintain skin physiological function.
PN AND PDRN
Polynucleotides (PNs) refer to as a broader group of molecules. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are all PNs. On the other hand, PRDN – Polydeoxyribonucleotides, refer to a subtype of PNs. Luna contains PNs – which also includes PDRN. These molecules contain large amounts of omega-3 fatty acids and are packed with anti-oxidant properties (Anti-oxidants neutralize free radicals which are harmful to our skin cells). Polynucleotide chains are DNA fragments that repair damaged dermal (skin) cells and assist in collagen stimulation.
Most often you may hear other people calling it PDRN or PN too.
For your information, PN stands for polynucleotide which is basically an element our DNA is made of. While PDRN is also a type of PN which stands for Polydeoxyribonucleotides.
PN is a purer and more concentrated form of PDRN and has stronger regenerative properties.
The use of PN in skin rejuvenation is mainly based on its potent wound healing and anti-inflammatory properties. Many studies have shown that PN stimulates wound healing and cell growth. These molecules have been proven to stimulate long-term skin regeneration from within the inner skin layer, therefore improving skin elasticity, skin health and restores skin damage caused by harmful UV rays and ageing.
PN contributes to the regeneration of several autologous key components of the skin such as glycosaminoglycan, proteins, glycoproteins, and fibrils, helping to maintain skin physiological function.
What is Plenhyage XL?
Plenhyage XL is an advanced injectable treatment primarily aimed at skin regeneration and repair. It utilizes polynucleotides, specifically polydeoxyribonucleotides (PDRN), which are DNA fragments derived from salmon. This formulation encourages the skin to repair itself by stimulating fibroblasts—cells responsible for collagen and elastin production. This cellular stimulation boosts hydration, enhances elasticity, and supports collagen synthesis, providing a rejuvenated, thicker, and more resilient skin texture.
Unlike traditional fillers, Plenhyage XL works not by adding volume but by regenerating the skin’s structural integrity, making it particularly effective for treating wrinkles, fine lines, and uneven skin tone. It is also versatile enough to treat areas beyond the face, including the neck, décolletage, and even the inner arms, knees, and thighs, targeting skin laxity and improving firmness. The treatment’s regenerative properties make it effective for addressing challenging skin issues such as acne scars, hyperpigmentation, and rosacea, along with the general signs of aging.
Treatment is quick, typically requiring minimal downtime, with results emerging within 2–4 weeks and continuing to improve over a few months. For optimal results, a series of three treatments spaced over several weeks is recommended, with effects lasting around six to nine months. While Plenhyage XL is generally painless, some clinics offer a numbing cream for comfort.
This unique product has gained popularity for its ability to rejuvenate skin from within rather than simply masking imperfections,
Plenhyage xl is the highest polynucleotide on the market at a massive 50mg per 2ml syringe
The NEWEST treatment is a recent innovation in skin aesthetics that combines polynucleotides with hyaluronic acid to promote skin regeneration, hydration, and elasticity. Created by Mastelli, this treatment uses polynucleotides derived from fish DNA, specifically selected to stimulate skin fibroblasts, enhance collagen production, and improve the structural integrity of the dermis. When injected, polynucleotides serve as biostimulants, triggering cellular repair processes and providing antioxidant protection by neutralizing free radicals. These properties help address signs of aging, such as fine lines, sagging skin, and uneven texture, while also improving skin hydration and volume.
Hyaluronic acid, also a component of NEWEST, is a well-known hydrating agent that helps retain moisture within the skin, keeping it supple and reducing dryness that often leads to wrinkles. When combined with polynucleotides, hyaluronic acid enhances the treatment’s effects, especially in areas like the face, neck, and décolleté, making it suitable for individuals with mature or dehydrated skin.
NEWEST treatment typically involves multiple sessions, with gradual improvements visible over time. Commonly treated areas include the under-eye, cheeks, and neck, and results may include reduced acne scars, less hyperpigmentation, and a healthier skin glow. Maintenance treatments every 6-12 months can help sustain these effects, providing lasting improvements in skin quality and appearance
What is Newest?
LETS COMPARE
Polynucleotide & Hyluronic Acid
Benefits of Polynucleotides:
Stimulate collagen and elastin production
Improve tone, firmness and resilience
Soften fine lines and wrinkles
Brighten complexion
Smoother skin texture
Non-invasive with no downtime
Can be used on face and body
Safe for all skin types
Best Thing For Under Eye Lines
Fibroblast stimulation from polynucleotides directly supports collagen production, which is essential for maintaining the skin’s structure and thickness. This collagen boost adds volume and strength to the skin, helping it appear firmer and denser resulting in less creepiness.
Polynucleotides have hygroscopic properties, meaning they attract and hold water in the skin. This hydration plumps the skin, making it appear thicker and more resilient. Additionally, well-hydrated skin cells function more effectively, further supporting skin regeneration and repair.
Polynucleotides also have antioxidant effects, which protect the skin from oxidative damage caused by environmental stressors like UV radiation and pollution. This protection reduces cellular damage and inflammation, which, over time, supports skin repair and thickening.
by supporting collagen and elastin levels and aiding in hydration, polynucleotides can improve the overall elasticity and firmness of the skin. Enhanced elasticity helps the skin resist sagging and thinning, maintaining a thicker, more youthful appearance over time.
Most Asked Q&A
Most Asked Q&A
Most Asked Q&A Most Asked Q&A
How Long Does It Take for Polynucleotide Injections to Work?
Like other injectables, polynucleotides also require a period of downtime and maintenance treatments for optimal efficacy. Whilst this completely depends on your patients aims and the product you choose to use, we recommend that your patient undergoes a course of at least three treatments for maximum results.
Again, whilst it may differ from patient to patient, most people notice a difference after 3-5 weeks, with the target results expected from 3+ months after the course of treatment has been issued. By recommending your patient undergo a series of treatments, you can ensure continued active stimulation of fibroblast production which will essentially maximise both the short and long-term results.
Moreover, for each treatment, it will depend on the degree of ageing that your patients’ tissue has and its ability to create quality tissue when stimulated by the polynucleotide It’s also crucial for you to remind your patients on the importance of a healthy diet, reducing alcohol consumption and smoking and to also follow a nutritious diet to help repair the skin holistically.
How often should I have polynucleotides?
When and how often should I have Polynucleotides? Polynucleotides are suitable at any age, at any time of year. Whilst there is a benefit to having even one syringe of polynucleotides, we recommend a course of at least 3, each spaced 3 weeks apart.
How long do polynucleotides last?
The improvements in skin condition and quality can usually last between six and nine months. Re-injection is then recommended to prolong results.
What are 2 examples of polynucleotides?
DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) are examples of polynucleotides. In DNA there are two spiral chains of polynucleotide which are arranged in a helical fashion, while RNA is a single-stranded molecule.
Are polynucleotide injections safe?
Polynucleotides are generally well-tolerated. There main potential side effects relate to the site of the injection i.e. redness, swelling, bruising. More serious side effects, such as allergic reactions, are rare.
What are polynucleotides used for?
Excellent at boosting fibroblast production and inducing deep tissue repair processes, polynucleotides enhance the skin's quality whilst also aiding with other concerns. Some other key usages of polynucleotides include: Acne scarring. Skin conditions such as rosacea, melasma and hyperpigmentation.
Is polynucleotide treatment painful?
Polynucleotide treatment involves injections, so the experience can be likened to other injectable procedures. The level of discomfort varies from person to person, but many patients describe the sensation as a slight pinch or sting during the injection.